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Purification of the soul series

on November 18, 2023

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(43) Purification of the Soul Series - YouTube

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Fibrillary GN

Notes from Handbook of GN Font: IBM Plex Sans Arabic INTRODUCTION 1. Rare 2. 1st described in 1977 by Rosenman and Eliakim 3. Recognized as a distinct entity by Duffy et al in 1983 4. Alpers coined the term 'FGN' in 1987 when describing 7 patients with non-CONGOphilic fibrillar glomerular deposits 5. Traditional definition of FGN glomerular deposition of Congo-red negative- RANDOMly oriented fibrils that lack a hollow centre at magnification <30K. stain with immunoglobulins (Igs) by immunofluoroscence (IF) 6. initially thought to be idiopathic 7. recent series revelaed association in some patients with Autoimmune disease malignancy Hepatitis C 8. No curative treatment for FGN 9. Rituximab stabilize kidney function ↓ proteinuria in some patients https://academic.oup.com/ndt/article/36/1/104/5866684?login=false The conclusion = Treatment of patients with two courses of rituximab over a span of 6 months was associated with stabilization o...

BAKKAH

BAKKAH Comparative Religious Study Series: Islam is the truth. Episode 1: It is mentioned in the Quran that the first house i.e. Kaabah was built in Bakkah. Bakkah is the older name for Makkah. Now let us look at the bible. Psalm 84 1 How lovely is Your dwelling place, O LORD of Hosts! 2 My soul longs, even faints, for the courts of the LORD; my heart and my flesh cry out for the living God. 3 Even the sparrow has found a home, and the swallow a nest for herself, where she places her young near Your altars, O LORD of Hosts, my King and my God. 4 How blessed are those who dwell in Your house! They are ever praising You. Selah 5 Blessed are those whose strength is in You, whose hearts are set on pilgrimage. 6 As they pass through the Valley of Baca, b they make it a place of springs; even the autumn rain covers it with pools. c 7 They go from strength to strength, until each appears before God in Zion. 8 O LORD God of Hosts, hear my prayer; give ear, ...

Kidney Biopsy of PSGN

Most common histology = diffuse proliferative GN with significant endocapillary proliferation LM: - involvement of all glomeruli - an influx of neutrophils into the glomerular capillaries - proliferation of the capillary endothelial cells - the capillary lumens are virtually obliterated, reducing the area of ultrafiltration, which leads to a loss of GFR. EM: the etiology for the inflammation is seen by the presence of immune complexes in the subepithelial space. The subepithelial deposits are often called "humps because they protrude outward on top of the GBM. IF: 1. The presence of these immune complexes results in a 'granular' appearance by IF using IgG and C3, with additional terminology for this phenomenon being starry sky or garland patterns 2. Additional immune deposits can be noted in the subendothelial space and mesangium. It should be noted that a kidney biopsy is usually not done in straightforward cases of PSGN because the treatment will n...

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Purification of the soul series

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